At least the Split Stick, a double-ended USB stick from Quirky, will keep your home and office files separate. Each end of this stick houses a retractable 4 GB USB drive. The Split Stick is made of rubber-coated anodized aluminum; available colors are black, pink, or orange. You can choose from a variety of etched designs to identify the data: look/lock, plus/minus, home/work, or others. The Split Stick is $24.99, directly from Quirky.
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Just in case, you forget to create separate folders for home and office.
How about two thumb drives glued end to end?